If you’re new to type design the best thing to do is going into it assuming that your early work will be awful and unoriginal. Free yourself to focus on learning. Then, after you get the hang of it, worry about making something good.

I agree with James. My first attempts were awful. But they gave me practice, and an opportunity to make mistakes.

FontStruct is certainly helpful, in that it provides a grid and building blocks. But you could sit down with notebook and pencil and sketch out your ideas first. (Many designers sketch out a few representative characters, like H and O, but you can start wherever you like: A, N, E... etc.)

You'll find some how-to advice here:

http://typophile.com/node/13083

Briem's site is very helpful.

So is Underware's Type Basics.

In terms of method, designing a typeface with FontStruct is not very different from designing with other font editors.

I normally start by designing the most "influential" letters first: n o H O (to define the main proportions and rhythm) and a e g s (to define the font's personality). Once you find a comfortable resolution to build these glyphs in your design, the rest follows naturally. :-)

Making your FontStruction public for other users to comment is also a great way to get feedback and improve your design.

I hope this helps // see you on FontStruct!

Thank you guys so much. All this info will help a lot. Especially the parts about the letters to start with. I guess it's a lot better than starting with A, then B, etc.
J