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Found the following at Garrick Van Buren's "Kernest" and figured Garrick might have better luck with an answer here at Typophile:
A basic example of this: PDFs might be rendered via a browser plugin or the browser might hand it over to Preview.app.
With the adoption of @font-face and the corresponding proliferation of embedded fonts - is a font-specific MIME type needed?
Anne van Kesteren asked this question back in 2008 - and the closest answer I can find is ‘application/octet-stream‘ might be fine (since it already exists) but it definitely doesn’t feel clean.